Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia

Citation
Cr. Breese et al., Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia, NEUROPSYCH, 23(4), 2000, pp. 351-364
Citations number
77
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPSYCHOPHARMACOLOGY
ISSN journal
0893-133X → ACNP
Volume
23
Issue
4
Year of publication
2000
Pages
351 - 364
Database
ISI
SICI code
0893-133X(200010)23:4<351:AROHAN>2.0.ZU;2-S
Abstract
Previous studies have suggested that an abnormality in neuronal nicotinic a cetylcholine receptor expression or function may be involved in the neuropa thophysiology of schizophrenia. [H-3]-nicotine and [H-3]-epibatidine bindin g were compared in postmortem brain from control and schizophrenic subjects with varying smoking histories. In control subjects, increased receptor bi nding was seen in hippocampus, cortex, and caudate with increasing tobacco use. In contrast, schizophrenic smokers had reduced nicotinic receptor leve ls in these brain regions compared to control smokers. Chronic haloperidol and nicotine treatment, in the rat, was used to assess neuroleptic effects on receptor up-regulation by nicotine. A significant increase in cortical n icotinic receptors was seen in both nicotine treated as well as haloperidol and nicotine co-treated animals, suggesting that the abnormal regulation o f high affinity neuronal nicotinic receptors in schizophrenics following ni cotine use was not related to chronic neuroleptic treatment. (C) 2000 Ameri can College of Neuropsychopharmacology. Published by Elsevier Science Inc.