Hypersegmentation of inflammatory cells in Langerhans cell granulomatosis

Citation
S. Wakatsuki et al., Hypersegmentation of inflammatory cells in Langerhans cell granulomatosis, DIAGN CYTOP, 23(4), 2000, pp. 238-241
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
DIAGNOSTIC CYTOPATHOLOGY
ISSN journal
8755-1039 → ACNP
Volume
23
Issue
4
Year of publication
2000
Pages
238 - 241
Database
ISI
SICI code
8755-1039(200010)23:4<238:HOICIL>2.0.ZU;2-W
Abstract
Langerhans cell granulomatosis (LCG) is characterized by a mixture of Lange rhans cells and eosinophils in varying proportions. The characteristic morp hology of Langerhans cells have already been described in many articles, bu r little attention has been paid to inflammatory cells. We examined sir cas es of Langerhans cell granulomatosis, which had originally been diagnosed a s eosinophilic granuloma. Inflammatory cells present in LCG showed hyperseg mentation. Twenty percent to 70% of eosinophils herd three or more segmente d nuclei, and 10-25% of neutrophils had five or more segmented nuclei. Such findings have never been described, and we believe hypersegmentation to be a feature of LCG. Furthermore, we emphasize that eosinophils in LCG mimic neutrophils in ethanol-fixed preparations, and thus may be a pitfall in mak ing a diagnosis in cytology and intraoperative consultation. (C) 2000 Wiley -Liss, Inc.