The fractional urinary fluoride excretion in young children under stable fluoride intake conditions

Citation
A. Villa et al., The fractional urinary fluoride excretion in young children under stable fluoride intake conditions, COMM DEN OR, 28(5), 2000, pp. 344-355
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
ISSN journal
0301-5661 → ACNP
Volume
28
Issue
5
Year of publication
2000
Pages
344 - 355
Database
ISI
SICI code
0301-5661(200010)28:5<344:TFUFEI>2.0.ZU;2-E
Abstract
The purpose of this study was to determine the fraction of the total daily fluoride intake that is excreted through the urine (FUEF) of children aged 3-5 years under usual intake conditions. Participating children were reside nts of an area with a fluoride (F) concentration of 0.5-0.6 mg/L in their d rinking water. Assessments were made on two successive 24-h periods on 20 c hildren, measuring the total amount of fluoride ingested through liquid and food consumption, and from ingestion of fluoridated toothpaste (500 mu g F /g), together with the determination of the amount of fluoride excreted thr ough urine. Fluoride retention was also estimated assuming a constant avera ge F fraction of 10% excreted through faeces. It was found that the average proportion of liquids, solid foods, and toothpaste to the daily fluoride i ntake (1.02-mg F/day on average) were 40.8, 34.6, and 24.5%, respectively. The average FUEF value was 35.5% (95% C.I.=31.7-39.3%), and the estimated f ractional F retention was 54.5%. The present data suggest a slight relation ship between FUEF values and the inverse of the daily fluoride dose (1/dose ) (r=0.513; P=0.021). When the present results are combined with those from previous studies on F-retention and urinary excretion, the correlation bet ween both FUEF and fractional retention and 1/dose are very strong and high ly significant (r=0.98, P<0.0001, and r=- 0.986, P<0.0001, respectively). A possible mechanism is suggested in order to explain this latter finding. T he potential usefulness of the current FUEF value for the estimation of dai ly F intake (or dose) from urinary F excretion data is also discussed.