Hypogonadism in patients treated with intrathecal morphine

Citation
Pm. Finch et al., Hypogonadism in patients treated with intrathecal morphine, CLIN J PAIN, 16(3), 2000, pp. 251-254
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology
Journal title
CLINICAL JOURNAL OF PAIN
ISSN journal
0749-8047 → ACNP
Volume
16
Issue
3
Year of publication
2000
Pages
251 - 254
Database
ISI
SICI code
0749-8047(200009)16:3<251:HIPTWI>2.0.ZU;2-C
Abstract
Objective: The objective of this study was to investigate the hypothalamic- pituitary-gonadal response to intrathecal opioids. Patients: Thirty patients receiving intrathecal morphine for chronic nonmal ignant pain were studied for clinical and biochemical evidence of hypogonad ism. Ten men and 10 postmenopausal women with chronic pain of similar durat ion but who were not receiving any form of opioid therapy acted as control subjects. Results: Men and both premenopausal and postmenopausal women had evidence o f hypogonadism with low levels of serum testosterone or estrogen coupled wi th low levels of pituitary gonadotrophins. Control subjects had hormone lev els in the expected range for their sex and age. Two men demonstrated recov ery after ceasing intrathecal opioid therapy. Conclusions: Hypogonadotrophic hypogonadism is a common complication of int rathecal opioid therapy in both men and women.