MAM: a "new" high-incidence antigen found on multiple cell lines

Citation
Wm. Montgomery et al., MAM: a "new" high-incidence antigen found on multiple cell lines, TRANSFUSION, 40(9), 2000, pp. 1132-1139
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
TRANSFUSION
ISSN journal
0041-1132 → ACNP
Volume
40
Issue
9
Year of publication
2000
Pages
1132 - 1139
Database
ISI
SICI code
0041-1132(200009)40:9<1132:MA"HAF>2.0.ZU;2-3
Abstract
BACKGROUND: Three women have been identified with an antibody to a "new" hi gh-incidence antigen found on multiple cell lines. CASE REPORTS: The proposita, M.A.M., presented during her third pregnancy w ith an antibody reacting with all RBCs tested except her own. She delivered a thrombocytopenic infant with a 3+ DAT, but without symptoms of HDN. The second example, A.N., presented during her third pregnancy with an antibody reacting with all RBCs tested except her own and those of M.A.M. She deliv ered a slightly thrombocytopenic but severely anemic infant. The third exam ple, F.K., a sister of A.N., has an antibody reacting with all RBCs tested except her own and those of M.A.M. and A.N. CONCLUSION: This "new" high-incidence antigen has been named MAM and assign ed high-incidence antigen number 901016 by the International Society of Blo od Transfusion. The corresponding antibody, anti-MAM, has been shown to cau se HDN and has the potential to shorten RBC survival after the transfusion of incompatible RBC units, as determined by monocyte monolayer assay. Immun oblotting and flow cytometry show that this new antibody reacts with variou s WBC lines in addition to RBCs. This antibody also appears to react with p latelets in some assays.