Sympathetic neurite growth on central nervous system sections is region-specific and unaltered by aging

Citation
Db. Pettigrew et al., Sympathetic neurite growth on central nervous system sections is region-specific and unaltered by aging, NEUROBIOL A, 21(5), 2000, pp. 629-638
Citations number
57
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROBIOLOGY OF AGING
ISSN journal
0197-4580 → ACNP
Volume
21
Issue
5
Year of publication
2000
Pages
629 - 638
Database
ISI
SICI code
0197-4580(200009/10)21:5<629:SNGOCN>2.0.ZU;2-O
Abstract
Several lines of evidence suggest that the brain exhibits reduced plasticit y with aging. However, a variety of soluble neurite outgrowth-promoting fac tors, such as neurotrophins, are not decreased in the aged brain, and aged neurons do not possess dramatically reduced growth potential. The possibili ty that aging results in reduced baseline substrate-bound neurite outgrowth -promoting activity in the central nervous system (CNS) was evaluated using tissue section culture. There were clear differences between brain regions in the extent of neurite outgrowth on both young and aged brain sections. However, no differences in the extent of neurite outgrowth were observed as a function of age. These results suggest that aging of the rat CNS is not accompanied by major alterations in the baseline neurite outgrowth-promotin g substrate properties of the tissue. (C) 2000 Elsevier Science Inc. All ri ghts reserved.