Gln27Glu and Arg16Gly polymorphisms of the beta(2)-adrenergic receptor gene are not associated with obesity in Japanese men

Citation
T. Hayakawa et al., Gln27Glu and Arg16Gly polymorphisms of the beta(2)-adrenergic receptor gene are not associated with obesity in Japanese men, METABOLISM, 49(9), 2000, pp. 1215-1218
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN journal
0026-0495 → ACNP
Volume
49
Issue
9
Year of publication
2000
Pages
1215 - 1218
Database
ISI
SICI code
0026-0495(200009)49:9<1215:GAAPOT>2.0.ZU;2-K
Abstract
The beta(2)-adrenergic receptor (beta(2)AR), beta(3)AR, or uncoupling prote in 1 (UCP1) may play a pathogenic role in obesity. In Swedish Caucasians, a polymorphism at codon 27 (Gln27Glu) of the beta(2)AR gene was shown to be associated with obesity, but no such association was shown for a polymorphi sm of codon 16 (Arg16Gly). Thus, we investigated whether these polymorphism s contribute to obesity in 210 Japanese men. The frequencies of the Gln27Gl u and Arg16Gly polymorphisms were 0.05 and 0.48, respectively, and there wa s no association with obesity. A strong linkage disequilibrium between the Gln27Glu and Arg16Gly polymorphisms was shown, but there was no apparent ad ditive effect on the clinical or metabolic characteristics. Our results sug gest that the Gln27Glu and Arg16Gly polymorphisms of the beta(2)AR gene are not a major contributing factor to obesity in Japanese men. Copyright (C) 2000 by W.B. Saunders Company.