Parvovirus B19 infection associated with the production of anti-neutrophilcytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL)

Citation
Tnk. Chou et al., Parvovirus B19 infection associated with the production of anti-neutrophilcytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL), LUPUS, 9(7), 2000, pp. 551-554
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Rheumatology
Journal title
LUPUS
ISSN journal
0961-2033 → ACNP
Volume
9
Issue
7
Year of publication
2000
Pages
551 - 554
Database
ISI
SICI code
0961-2033(2000)9:7<551:PBIAWT>2.0.ZU;2-G
Abstract
We described four patients who had clinical diagnosis of erythema infectios um and presented with skin rash, polyarthralgia, polyarthritis, and mild fe ver. Anti-parvovirus B19 IgM and IgG antibodies were found in all four pati ents and parvovirus B19 DNA was detected in three of the four patients by p olymerase chain reaction (PCR) in sera using standard methods. Anticardioli pin antibody (aCL) was positive in three of the four patients included thre e with anti-beta 2 glycoprotein I (beta 2GPI). The immunoglobulin isotype o f aCL was found to be IgM. Anti-neutrophil cytoplasmic antibody (ANCA) incl uded three p-ANCA and one c-ANCA was detected in all four patients by indir ect immunofluoresence (IIF). Both anti-proteinase 3 (PR3) and anti-myeloper oxidase (MPO) antibodies were found in two patients whom had polyarthritis for more than 6 months. These data indicate parvovirus B19 may be linked to the induction of an autoimmune response.