Aim of the study. Investigation of the quantitative microcirculation parame
ters amplitude A and exchange fate constant k(21) determined by contrast-en
hanced dynamic magnetic resonance imaging (d-MRI) in multiple myeloma (MM).
Methods. d-MRT of lumbar spine and right spina iliaca superior posterior of
16 controls (ctr) and 35 patients with active MM. Generation of colour-cod
ed images of microcirculation parameters superimposed onto static MRI image
Results. Amplitude A and k(21) parameters were significantly increased in p
atients with MM and down modulated by therapy in 7 of 8 MM cases in a follo
w-up investigation [p<0.01; median A(ctr)=0.2 (0.09-0.4); median A(MM)=0.93
(0.2-1.52); median k(21ctr)=0.09 min(-1) (0.03-0.9); median k(21ctr)=4.57
min(-1) (0.21-23.8)]. Thirteen patients revealed a "diffuse" and 22 a "foca
l" pattern of distribution of microcirculation parameters. Bone marrow biop
sies in 8 cases revealed an correlation between bone marrow plasma cell inf
iltration and increased microcirculation parameters.
Conclusion. Identification of microcirculation changes by d-MRI is a novel
imaging technique far the detection and monitoring of MM bone lesions.