Functional magnetic resonance imaging for detection and monitoring of bonelesions in multiple myeloma

Citation
Tm. Moehler et al., Functional magnetic resonance imaging for detection and monitoring of bonelesions in multiple myeloma, RADIOLOGE, 40(8), 2000, pp. 723-730
Citations number
25
Language
TEDESCO
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
RADIOLOGE
ISSN journal
0033-832X → ACNP
Volume
40
Issue
8
Year of publication
2000
Pages
723 - 730
Database
ISI
SICI code
0033-832X(200008)40:8<723:FMRIFD>2.0.ZU;2-5
Abstract
Aim of the study. Investigation of the quantitative microcirculation parame ters amplitude A and exchange fate constant k(21) determined by contrast-en hanced dynamic magnetic resonance imaging (d-MRI) in multiple myeloma (MM). Methods. d-MRT of lumbar spine and right spina iliaca superior posterior of 16 controls (ctr) and 35 patients with active MM. Generation of colour-cod ed images of microcirculation parameters superimposed onto static MRI image s. Results. Amplitude A and k(21) parameters were significantly increased in p atients with MM and down modulated by therapy in 7 of 8 MM cases in a follo w-up investigation [p<0.01; median A(ctr)=0.2 (0.09-0.4); median A(MM)=0.93 (0.2-1.52); median k(21ctr)=0.09 min(-1) (0.03-0.9); median k(21ctr)=4.57 min(-1) (0.21-23.8)]. Thirteen patients revealed a "diffuse" and 22 a "foca l" pattern of distribution of microcirculation parameters. Bone marrow biop sies in 8 cases revealed an correlation between bone marrow plasma cell inf iltration and increased microcirculation parameters. Conclusion. Identification of microcirculation changes by d-MRI is a novel imaging technique far the detection and monitoring of MM bone lesions.