CRYOFIBRINOGENEMIA WITH POLYARTHRALGIA, RAYNAUDS-PHENOMENON AND ACRALULCER IN A PATIENT WITH GRAVES-DISEASE TREATED WITH METHIMAZOLE

Citation
K. Hosoi et al., CRYOFIBRINOGENEMIA WITH POLYARTHRALGIA, RAYNAUDS-PHENOMENON AND ACRALULCER IN A PATIENT WITH GRAVES-DISEASE TREATED WITH METHIMAZOLE, Internal medicine, 36(6), 1997, pp. 439-442
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0918-2918
Volume
36
Issue
6
Year of publication
1997
Pages
439 - 442
Database
ISI
SICI code
0918-2918(1997)36:6<439:CWPRAA>2.0.ZU;2-2
Abstract
Cryofibrinogenemia is a cryopathy in which hypersensitivity to cold is a prominent feature, Cryofibrinogenemia developed in an 18-year-old J apanese female patient during methimazole therapy for Graves' disease, She developed cryopathy (livedo reticularis, Raynaud's phenomenon and acral ulcer) and polyarthralgia during methimazole therapy, and we de tected cryofibrinogen in her plasma. Her symptoms resolved after admin istration of prostaglandins and anticoagulants, Several reports indica te that methimazole therapy induces autoantibody-related disease. In t he present case, we cannot exclude the possibility that methimazole th erapy contributed to the cryofibrinogenemia.