Blood pressure responses to high-calcium skim milk and potassium-enriched high-calcium skim milk

Citation
Jh. Green et al., Blood pressure responses to high-calcium skim milk and potassium-enriched high-calcium skim milk, J HYPERTENS, 18(9), 2000, pp. 1331-1339
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF HYPERTENSION
ISSN journal
0263-6352 → ACNP
Volume
18
Issue
9
Year of publication
2000
Pages
1331 - 1339
Database
ISI
SICI code
0263-6352(200009)18:9<1331:BPRTHS>2.0.ZU;2-0
Abstract
Objective This study was designed to evaluate the effect of high-calcium sk im milk or potassium-enriched high-calcium skim milk on blood pressure comp ared with nonenriched skim milk, Design This was a randomized double-blind controlled trial. Each milk inter vention lasted for 4 weeks, with a minimum of 4 weeks of wash-out between i nterventions. Methods We recruited 38 healthy people, aged over 40 years, to take part in a double-blind, randomized, controlled cross-over study. We asked them to replace their usual liquid milk with two servings per day of skim milk (con trol), high-calcium skim milk or potassium-enriched high-calcium skim milk. We measured office blood pressures (seated and standing) at the start and after 2 and 4 weeks of milk intervention and we measured daytime ambulatory blood pressures at the start and after 4 weeks of milk intervention, Each milk intervention was interspaced by a 4-week interval. Results Office systolic blood pressure (standing) decreased from 127 +/- 16 to 124 +/- 16 mmHg (P < 0.05) after 4 weeks of skim milk and from 130 +/- 18 to 126 +/- 17 mmHg (P < 0.05) after 4 weeks of high calcium skim milk. A fter 4 weeks of consuming the potassium-enriched high-calcium milk, systoli c blood pressure decreased from 125 +/- 18 to 117 +/- 16 mmHg (P < 0.001) s eated, and from 130 +/- 16 to 122 +/- 15 mmHg (P < 0.001) standing. There w ere no significant changes in office diastolic blood pressure after any mil k. There was no change in ambulatory blood pressure after either skim milk or high-calcium skim milk. After 4 weeks of potassium-enriched high-calcium milk, ambulatory daytime systolic blood pressure decreased from 138 +/- 13 to 135 +/- 11 mm Hg (P< 0.05) and daytime diastolic blood pressure decreas ed from 80 +/- 8 to 78 +/- 9 mmHg (P < 0.05), Conclusions High-calcium milk enriched with potassium has a small hypotensi ve effect in healthy people aged over 40 years. J Hypertens 2000, 18:1331-1 339 (C) Lippincott Williams & Wilkins.