The effects of atropine and adrenergic antagonists on behavioral arousal in rats

Citation
C. Wilson et al., The effects of atropine and adrenergic antagonists on behavioral arousal in rats, J GEN PSYCH, 127(3), 2000, pp. 249-260
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psycology
Journal title
JOURNAL OF GENERAL PSYCHOLOGY
ISSN journal
0022-1309 → ACNP
Volume
127
Issue
3
Year of publication
2000
Pages
249 - 260
Database
ISI
SICI code
0022-1309(200007)127:3<249:TEOAAA>2.0.ZU;2-Q
Abstract
Two experiments investigated the mechanism for changes in measures of behav ioral arousal inhibition in rats following administration of atropine. In E xperiment 1, 40-day-old rats were given administrations of atropine sulfate , the alpha-, beta-adrenergic blocker labetalol, or both. The drugs, either alone or in combination, increased transport response intensity, whereas b oth together increased dorsal immobility durations. In Experiment 2, rats w ere given atropine, the beta-adrenergic antagonist propranolol, the a-adren ergic antagonist phentolamine, or a combination of two of the drugs. Propra nolol blocked atropine-induced increases in transport response, and phentol amine was without effect. Phentolamine, when combined with atropine, increa sed dorsal immobility durations. Results are discussed with respect to aspe cts common to both transport response and dorsal immobility.