The authors describe the cases of three patients presenting a major extrapy
ramidal symptom with rising CPK, inconstant hyperthermia and autonomic dysf
unction. Through a brief review of the literature, the authors question the
unity of the malignant syndrome. If hypertonia is quite constant, the rise
in the seric CPK is aspecific and hyperthermia is inconstant. (C) 2000 Edi
tions scientifiques et medicales Elsevier SAS.