Coffee consumption and decreased serum gamma-glutamyltransferase: a study of middle-aged Japanese men

Citation
N. Nakanishi et al., Coffee consumption and decreased serum gamma-glutamyltransferase: a study of middle-aged Japanese men, EUR J EPID, 16(5), 2000, pp. 419-423
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF EPIDEMIOLOGY
ISSN journal
0393-2990 → ACNP
Volume
16
Issue
5
Year of publication
2000
Pages
419 - 423
Database
ISI
SICI code
0393-2990(200005)16:5<419:CCADSG>2.0.ZU;2-Z
Abstract
The potential inverse association between coffee intake and serum gamma-glu tamyltransferase (GGT) was examined in a cross-sectional study involving 13 53 Japanese male office workers aged 35-59 years in Osaka, Japan. Those who had serum aminotransferases exceeding the normal range and/or who had been administered medical care for, or had a past history of, liver disease wer e excluded. Multiple linear regression analysis and analysis of covariance were used to control for confounding variables (age, body mass index, alcoh ol use, and cigarette smoking) and to examine possible interactions. From t he linear regression analysis, coffee intake was inversely related to serum GGT levels independently of age, body mass index, alcohol intake, and ciga rette smoking. All of the latter variables were also independently and posi tively associated with serum GGT levels. When the interactions between coff ee and each of four covariates on serum GGT were evaluated by adding each i nteraction term to the above regression model, significant negative interac tions were observed for age and cigarette smoking. From the analysis of cov ariance, lower levels of serum GGT associated with coffee consumption were more evident in the older age group and at the higher levels of cigarette s moking. These findings suggest that coffee consumption is inversely related to serum GGT and that coffee may inhibit the inducing effects of aging and possibly of smoking on serum GGT in the liver.