Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan)

Citation
T. Takezaki et al., Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan), CANC CAUSE, 11(7), 2000, pp. 597-608
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Envirnomentale Medicine & Public Health
Journal title
CANCER CAUSES & CONTROL
ISSN journal
0957-5243 → ACNP
Volume
11
Issue
7
Year of publication
2000
Pages
597 - 608
Database
ISI
SICI code
0957-5243(200008)11:7<597:SRFFHA>2.0.ZU;2-L
Abstract
Objectives: To clarify subsite-specific risk factors for hypopharyngeal and esophageal cancers (HC and EC), we concluded a hospital-based case-referen t study in Nagoya, Japan. Methods: Subjects comprised 346 male cases with cancer of the hypopharynx ( n = 62) or esophagus (upper [U-EC] 53, middle [M-EC] 159, lower [L-EC] 72), and 11,936 male referents free from cancer among first-visit outpatients a ged 40-79 years in 1988-1997. Of histological confirmed cases, 93% comprise d squamous cell carcinoma. Odds ratios (ORs) were estimated by a logistic r egression model with adjustment for potential confounding factors. Results: Cigarette smoking increased the OR for M-EC, and alcohol drinking elevated the ORs for all subsites. The trend of ORs for combined cases of M - and L-EC tended to increase with number of cigarettes (p = 0.056), and a decreasing trend of the ORs was found with years after quitting smoking (p = 0.006). The ORs for smoking with drinking were multiplicatively greater t han those for smoking or drinking in combined cases of HC and EC. In contra st, daily raw vegetable consumption lowered the ORs for all subsites. Conclusions: This study suggests that the magnitude of risk with smoking is stronger for M-EC within the esophagus, and drinking increases the risk at any subsite.