Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets

Citation
F. Kerbaul et al., Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets, BR J ANAEST, 85(3), 2000, pp. 440-445
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF ANAESTHESIA
ISSN journal
0007-0912 → ACNP
Volume
85
Issue
3
Year of publication
2000
Pages
440 - 445
Database
ISI
SICI code
0007-0912(200009)85:3<440:EOSOHP>2.0.ZU;2-8
Abstract
In vitro, halogenated agents reduce the pulmonary vasoconstrictor response to alveolar hypoxia in isolated perfused lungs. However, studies in intact animals have been less convincing. The aim of the present study was to asse ss the effect of sevoflurane on hypoxic pulmonary vasoconstriction (HPV) in anaesthetized piglets using the pressure/cardiac index relationship (P/Q). Ten large white piglets were anaesthetized and mechanically ventilated, al ternately in hyperoxia (FIO2 = 0.4) and hypoxia (FIO2= 0.12). Multipoint pl ots of pulmonary arterial pressure (PAP) or differences between PAP and lef t atrial pressure (LAP) against Q were generated by gradual inflation of a balloon introduced into the inferior vena cava. P/Q relationships were esta blished in hyperoxia and hypoxia at baseline, and then with sevoflurane. In hypoxia, pressure gradients (PAP - LAP) increased at every level of Q, thu s demonstrating active pulmonary vasoconstriction. Sevoflurane at 1 MAC did not affect these P/Q relationships in hyperoxia or hypoxia as compared wit h baseline. Sevoflurane at a clinically relevant concentration (1 MAC) has no significant effect on HPV in anaesthetized piglets.