Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation

Citation
Y. Kishi et al., Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation, BONE MAR TR, 26(5), 2000, pp. 573-576
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
0268-3369 → ACNP
Volume
26
Issue
5
Year of publication
2000
Pages
573 - 576
Database
ISI
SICI code
0268-3369(200009)26:5<573:DLIFTO>2.0.ZU;2-8
Abstract
We describe two patients who developed respiratory syncytial virus (RSV) pn eumonia after BMT, One died of RSV pneumonia after three courses of steroid pulse therapy. Surprisingly, RSV antigen was identified in the bronchoalve olar lavage fluid (BALF) obtained post mortem, Steroid pulse therapy might have suppressed anti-RSV immunity, leading to persistent RSV infection for more than 1 month. The other patient received donor lymphocyte infusions (D LI) for relapsed plasma cell leukemia, while having active RSV pneumonia, H is respiratory condition improved after DLI, and RSV antigen disappeared in BALF and nasal swabs, DLI might be effective in cases of life-threatening RSV pneumonia.