Y. Kishi et al., Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation, BONE MAR TR, 26(5), 2000, pp. 573-576
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
We describe two patients who developed respiratory syncytial virus (RSV) pn
eumonia after BMT, One died of RSV pneumonia after three courses of steroid
pulse therapy. Surprisingly, RSV antigen was identified in the bronchoalve
olar lavage fluid (BALF) obtained post mortem, Steroid pulse therapy might
have suppressed anti-RSV immunity, leading to persistent RSV infection for
more than 1 month. The other patient received donor lymphocyte infusions (D
LI) for relapsed plasma cell leukemia, while having active RSV pneumonia, H
is respiratory condition improved after DLI, and RSV antigen disappeared in
BALF and nasal swabs, DLI might be effective in cases of life-threatening
RSV pneumonia.