The MeOH extract of Epimedium sagittatum was found to show neurite outgrowt
h activity on cultured PC12h cells. Bioassay-guided fractionation of the Me
OH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), i
carisid II (2), epimedoside A (3), icariin (4), epimedin B (5), and epimedo
koreanoside-I (6) as the active ingredients.