Intravenous pretreatment with magnolol protects myocardium against stunning

Citation
Ch. Huang et al., Intravenous pretreatment with magnolol protects myocardium against stunning, PLANTA MED, 66(6), 2000, pp. 516-520
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
0032-0943 → ACNP
Volume
66
Issue
6
Year of publication
2000
Pages
516 - 520
Database
ISI
SICI code
0032-0943(200008)66:6<516:IPWMPM>2.0.ZU;2-D
Abstract
Magnolol, an antioxidant, has been reported to possess various protective e ffects on the cardiovascular system. However, its effect on myocardial stun ning has not been elucidated. The purpose of this study was to investigate the anti-stunning effect of magnolol by evaluating the recovery of regional myocardial function after 10-minute coronary artery occlusion in anestheti zed, open-chest rabbits. There was no significant hemodynamic change after intravenous infusion of magnolol. Systolic wall thickening fraction (WThF) measured with an epicardial Doppler sensor in animals pretreated with norma l saline and vehicle solution remained significantly depressed (60 +/- 7% a nd 77 +/- 4% of baseline WThF, respectively) 3 hours after coronary artery reperfusion (CAR). Pretreatment with magnolol (10(-7) and 10(-6) g/kg, intr avenous infusion) significantly enhanced the recovery of systolic wall thic kening fraction (98 +/- 1 and 99 +/- 4% of baseline WThF, respectively) 60 minutes after CAR. This study demonstrated that intravenous pretreatment wi th magnolol protected myocardium against stunning.