Chemical model for phosphine-induced lipid peroxidation

Citation
Gb. Quistad et al., Chemical model for phosphine-induced lipid peroxidation, PEST MAN SC, 56(9), 2000, pp. 779-783
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Entomology/Pest Control
Journal title
PEST MANAGEMENT SCIENCE
ISSN journal
1526-498X → ACNP
Volume
56
Issue
9
Year of publication
2000
Pages
779 - 783
Database
ISI
SICI code
1526-498X(200009)56:9<779:CMFPLP>2.0.ZU;2-Z
Abstract
Phosphine (PH3) from hydrolysis of metal phosphides is highly toxic and is important for control of stored-product insect pests (AlP, Mg3P2) and roden ts (Zn3P2). This fumigant inhibits respiration and induces lipid peroxidati on in insects and mammals. PH3 (from Mg3P2) and H2O2, acting for 15 min in phosphate buffer (pH 7.4), oxidized cod liver oil (high in unsaturated Lipi ds) to malondialdehyde. Both Mg3P2 and H2O2 were found to be necessary for this lipid peroxidation, which under optimal conditions produced a seven-fo ld increase in malondialdehyde relative to basal levels in cod liver oil wi th H2O2 but no PH3. Under the same conditions, 15-, 9- and 2-fold increases in malondialdehyde were obtained from ethyl arachidonate, methyl linoleate and methyl oleate. Small amounts of hydroxyl radical from PH3/H2O2 were tr apped with salicylic acid. Reactive oxygen species for Lipid peroxidation m ay therefore be derived from direct reaction of PH3 with H2O2 as an alterna tive hypothesis to their respiration-linked formation. (C) 2000 Society of Chemical Industry.