The novel gene glaikit, is expressed during neurogenesis in the Drosophilamelanogaster embryo

Citation
J. Dunlop et al., The novel gene glaikit, is expressed during neurogenesis in the Drosophilamelanogaster embryo, MECH DEVEL, 96(1), 2000, pp. 133-136
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
0925-4773 → ACNP
Volume
96
Issue
1
Year of publication
2000
Pages
133 - 136
Database
ISI
SICI code
0925-4773(200008)96:1<133:TNGGIE>2.0.ZU;2-G
Abstract
A novel gene glaikit (gkt) has been identified which is expressed in the de laminating neuroblasts of the D. melanogaster embryonic central nervous sys tem. At the earliest stages of embryonic development the expression of glai kit was ubiquitous, but by the time the neuroblasts are delaminating: gkt e xpression became restricted to neuroblasts and a few ganglion mother cells. The gkt gene has no characterized homologues and encodes no previously des cribed protein motifs. There are, however, evolutionary conserved predicted genes present in S. pombe, S. cerevisiae and C. elegans. Ectopic neuroblas ts induced in either Notch or Delta mutant backgrounds also showed expressi on of glaikit. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.