J. Schimana et al., Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities, J ANTIBIOT, 53(8), 2000, pp. 779-787
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were de
tected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC
-diode-array and HPLC-electrospray-mass-spectrometry screening. The compoun
ds show antibiotic activities against Gram-positive bacteria and cytostatic
effects on various tumor cell lines.