Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities

Citation
J. Schimana et al., Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities, J ANTIBIOT, 53(8), 2000, pp. 779-787
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
0021-8820 → ACNP
Volume
53
Issue
8
Year of publication
2000
Pages
779 - 787
Database
ISI
SICI code
0021-8820(200008)53:8<779:SNCAAP>2.0.ZU;2-5
Abstract
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were de tected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC -diode-array and HPLC-electrospray-mass-spectrometry screening. The compoun ds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.