Perinatal outcome of pregnancies complicated by diabetes and by maternal daily hyperglycemia not related to diabetes - A retrospective 10-year analysis
Mvc. Rudge et al., Perinatal outcome of pregnancies complicated by diabetes and by maternal daily hyperglycemia not related to diabetes - A retrospective 10-year analysis, GYNECOL OBS, 50(2), 2000, pp. 108-112
We analyzed the perinatal outcome of 1,086 pregnancies classified according
to the response to the 3-hour 100-gram glucose tolerance test and the diur
nal glycemic profile into the Rudge groups corresponding to control pregnan
t women, class A gestational diabetic women, class A/B to FRH pregnant wome
n and women with daily hyperglycemia, Despite treatment, the diabetic pregn
ant women and those with daily hyperglycemia presented higher mean blood gl
ucose levels compared to controls (76.6 +/- 10.2 mg/dl), The pregnancies co
mplicated by diabetes and by daily hyperglycemia were characterized by a hi
gh incidence of prematurity, macrosomia, large for gestational age newborn
infants, malformation and fetal and neonatal death, with consequent perinat
al mortality. The perinatal mortality of women with daily hyperglycemia was
10 times higher than that of the controls and was similar to that of the d
iabetic patients. These adverse perinatal results emphasize the need for th
e diagnosis and control of intrauterine hyperglycemia both in diabetic preg
nant women and in women with an altered diurnal glycemic profile. Copyright
(C) 2000 S. Karger AG, Basel.