Physical activity and coronary heart disease in men - The Harvard Alumni Health Study

Hd. Sesso et al., Physical activity and coronary heart disease in men - The Harvard Alumni Health Study, CIRCULATION, 102(9), 2000, pp. 975-980
Citations number
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
ISSN journal
0009-7322 → ACNP
Year of publication
975 - 980
SICI code
Background-The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefo re, we examined the association of the quantity and intensity of physical a ctivity with CHD risk and the impact of other coronary risk factors. Methods and Results-We followed 12 516 middle-aged and older men (mean age 57.7 years, range 39 to 88 years) from 1977 through 1993. Physical activity was assessed at baseline in kilojoules per week (4.2 kJ = 1 kcal) from blo cks walked, flights climbed, and participation in sports or recreational ac tivities. During follow-up, 2135 cases of incident CHD, including myocardia l infarction, angina pectoris, revascularization, and coronary death, occur red. Compared with men expending <2100 kJ/wk, men expending 2100 to 4199, 4 200 to 8399, 8400 to 12 599, and greater than or equal to 12 600 kJ/wk had multivariate relative risks of 0.90, 0.81, 0.80, and 0.81, respectively (P for trend = 0.003). When we considered the independent effects of specific physical activity components, only total sports or recreational activities (P for trend = 0.042) and vigorous activities (P for trend = 0.02) were inv ersely associated with the risk of CHD. These associations did not differ w ithin subgroups of men defined by coronary risk factors. Finally, among men with multiple coronary risk factors, those expending greater than or equal to 4200 kJ/wk had reduced CHD risk compared with men expending <4200 kJ/wk . Conclusions-Total physical activity and vigorous activities showed the stro ngest reductions in CHD risk. Moderate and light activities, which may be l ess precisely measured, showed nonsignificant inverse associations. The ass ociation between physical activity and a reduced risk of CHD also extends t o men with multiple coronary risk factors.