Signaling by reactive oxygen species in the nervous system

Citation
P. Maher et D. Schubert, Signaling by reactive oxygen species in the nervous system, CELL MOL L, 57(8-9), 2000, pp. 1287-1305
Citations number
131
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1287 - 1305
Database
ISI
SICI code
1420-682X(200008)57:8-9<1287:SBROSI>2.0.ZU;2-W
Abstract
Free radicals and reactive oxygen species (ROS) are involved in a variety o f different cellular processes ranging from apoptosis and necrosis to cell proliferation and carcinogenesis. Cells contain multiple sites for ROS prod uction and a few mechanisms for their degradation. Which of these sites is activated by a given stimulus may play a role in dictating the subsequent d ownstream effects of the ROS generated on cellular function. Even when the ultimate outcome is similar, such as when ROS production leads to cell deat h, the specific cellular changes can be quite different depending on the in itial stimulus and the type of cell involved. These data, along with the ev idence that ROS can modify a number of intracellular signaling pathways inc luding protein phosphatases, protein kinases and transcription factors, sug gest that the majority of the effects of ROS on cells are through their act ions on signaling pathways rather than via nonspecific damage of intracellu lar macromolecules.