Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores

Citation
Jw. Putney et Cmp. Ribeiro, Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores, CELL MOL L, 57(8-9), 2000, pp. 1272-1286
Citations number
166
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1272 - 1286
Database
ISI
SICI code
1420-682X(200008)57:8-9<1272:SPBTPM>2.0.ZU;2-R
Abstract
This review discusses multiple ways in which the endoplasmic reticulum part icipates in and is influenced by signal transduction pathways. The endoplas mic reticulum provides a Ca2+ store that can be mobilized either by calcium -induced calcium release or by the diffusible messenger inositol 1,4,5-tris phosphate. Depletion of endoplasmic reticulum Ca2+ stores provides a signal that activates surface membrane Ca2+ channels, a process known as capacita tive calcium entry. Depletion of endoplasmic reticulum stores can also sign al long-term cellular responses such as gene expression and programmed cell death or apoptosis. In addition to serving as a source of cellular signals , the endoplasmic reticulum is also functionally and structurally modified by the Ca2+ and protein kinase C pathways. Elevated cytoplasmic Ca2+ causes a rearrangement and fragmentation of endoplasmic reticulum membranes. Prot ein kinase C activation reduces the storage capacity of the endoplasmic ret iculum Ca2+ pool. In some cell types. protein kinase C inhibits capacitativ e calcium entry. Protein kinase C activation also protects the endoplasmic reticulum from the structural effects of high cytoplasmic Ca2+. The emergin g view is one of a complex network of pathways through which the endoplasmi c reticulum and the Ca2+ and protein kinase C signaling pathways interact a t various levels regulating cellular structure and function.