Peripheral B cell survival

Citation
F. Agenes et al., Peripheral B cell survival, CELL MOL L, 57(8-9), 2000, pp. 1220-1228
Citations number
84
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1220 - 1228
Database
ISI
SICI code
1420-682X(200008)57:8-9<1220:PBCS>2.0.ZU;2-Y
Abstract
Recent findings suggest that lymphocyte survival is a continuous active pro cess and support the role of B cell receptor engagement in B cell survival. In this context the conflict of survival interests between the diverse B c ells gives rise to a pattern of interactions which mimics the behavior of c omplex ecological systems. In response to competition lymphocytes modify th eir survival requirements and diverge to occupy different immunological nic hes through differentiation. Thus naive and memory-activated B cell populat ions show independent homeostatic regulation. We discuss how niche differen tiation allows the coexistence of different cell types and guarantees both repertoire diversity and efficient immune responses.