Regulation of gene expression by transcription factor acetylation

Citation
Aj. Bannister et Ea. Miska, Regulation of gene expression by transcription factor acetylation, CELL MOL L, 57(8-9), 2000, pp. 1184-1192
Citations number
58
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1184 - 1192
Database
ISI
SICI code
1420-682X(200008)57:8-9<1184:ROGEBT>2.0.ZU;2-N
Abstract
In the nucleus, DNA is tightly packaged into higher-order structures, gener ating an environment that is highly repressive towards DNA processes such a s gene transcription. Acetylation of lysine residues within proteins has re cently emerged as a major mechanism used by the cell to overcome this repre ssion. Acetylation of non-histone proteins. including transcription factors , as well as histones, appears to be involved in this process. Like phospho rylation, acetylation is a dynamic process that can regulate protein-DNA an d protein-protein interactions. Moreover, a conserved domain, the bromodoma in, has been implicated in the binding of acetylated peptides, suggesting a role fur acetylation in intracellular signalling.