Molecular basis of nutrient-controlled gene expression in Saccharomyces cerevisiae

Authors
Citation
Rj. Reece, Molecular basis of nutrient-controlled gene expression in Saccharomyces cerevisiae, CELL MOL L, 57(8-9), 2000, pp. 1161-1171
Citations number
73
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1161 - 1171
Database
ISI
SICI code
1420-682X(200008)57:8-9<1161:MBONGE>2.0.ZU;2-7
Abstract
The ability of a unicellular organism to alter patterns of gene expression in response to nutrient availability is essential to its survival in a chan ging environment. How is the cell able to identify individual metabolites a mongst a myriad of other similar molecules, and convert the information of its presence into a concerted change in the transcription of the genes requ ired for the response to that metabolite? There is increasing evidence that the activity of transcription factors can be influenced directly by intera ction with metabolites. A variety of mechanisms have been identified by whi ch this type of gene regulation by Small molecules can occur.