Mechanisms of action of transcription activation and repression domains

Authors
Citation
Sge. Roberts, Mechanisms of action of transcription activation and repression domains, CELL MOL L, 57(8-9), 2000, pp. 1149-1160
Citations number
104
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
8-9
Year of publication
2000
Pages
1149 - 1160
Database
ISI
SICI code
1420-682X(200008)57:8-9<1149:MOAOTA>2.0.ZU;2-D
Abstract
Transcriptional regulators contain domains that either activate or repress transcription. Indeed, many cellular transcriptional regulators contain bot h activation and repression domains. Transcriptional regulators act at seve ral stages in the transcription process, including assembly of the transcri ption complex, initiation and elongation. In order to influence these proce sses, the regulatory domains must interact with components of the transcrip tion apparatus. This review will focus on our current understanding of the nature of transcriptional regulatory domains and their targets in the trans cription machinery.