Reconstitution of humoral immunity during pregnancy

Citation
M. Narita et al., Reconstitution of humoral immunity during pregnancy, AM J REPROD, 44(3), 2000, pp. 148-152
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
3
Year of publication
2000
Pages
148 - 152
Database
ISI
SICI code
1046-7408(200009)44:3<148:ROHIDP>2.0.ZU;2-K
Abstract
BACKGROUND: Recently, increasing attention has been paid to hormonal regula tions of the immune system. MATERIALS AND METHODS: In this study, cord sera and the corresponding mater nal sera were obtained at delivery. Sera from pregnant women were obtained at early, middle, and late stages of pregnancy. These sera were tested for titer and avidity of measles or mumps virus-specific immunoglobulin G (IgG) by means of a single-dilution. urea-denaturation enzyme-linked immunosorbe nt assay method. RESULTS: A positive and significant correlation was found between the titer and avidity of the virus-specific Igc, both in the cord sera and in the ma ternal sera. This correlation was established already at the early stage of pregnancy. There were no such correlations found in nonpregnant individual s. CONCLUSIONS: This is the first observation in human subjects that the avidi ty and concentration of the virus-specific IgG had a positive and significa nt correlation. Pregnancy must have some significant effects on the regulat ion of humoral immunity.