Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Citation
P. Vermeulen et al., Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation, VIRCHOWS AR, 437(2), 2000, pp. 194-197
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
ISSN journal
0945-6317 → ACNP
Volume
437
Issue
2
Year of publication
2000
Pages
194 - 197
Database
ISI
SICI code
0945-6317(200008)437:2<194:BSC(OT>2.0.ZU;2-H
Abstract
A case of a man with biphasic sarcomatoid carcinoma of the right kidney wit h chondrosarcomatous foci and with invasion of the pelvic mucosa and submuc osa into the peripelvic adipose tissue is presented. In situ carcinoma of t he urothelium of the right renal pelvis and proximal ureter was also noted. Comments on the nomenclature of malignant tumours with apparently mixed ca rcinomatous and sarcomatous phenotypes and a hypothesis on the histogenesis of these tumours are presented. Cytokeratin and p53 protein expression pat terns, and the results of angiogenesis quantification are consistent with a n epithelial-to-mesenchymal conversion induced by the stroma.