Prevention of autoimmune type 1 diabetes via mucosal tolerance: Is mucosalautoantigen administration as safe and effective as it should?

Authors
Citation
A. Hanninen, Prevention of autoimmune type 1 diabetes via mucosal tolerance: Is mucosalautoantigen administration as safe and effective as it should?, SC J IMMUN, 52(3), 2000, pp. 217-225
Citations number
80
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Immunology
Journal title
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
ISSN journal
0300-9475 → ACNP
Volume
52
Issue
3
Year of publication
2000
Pages
217 - 225
Database
ISI
SICI code
0300-9475(200009)52:3<217:POAT1D>2.0.ZU;2-0
Abstract
Mucosal immune response to an antigen leads to a state of attenuated system ic response to the same antigen, known as mucosal or oral tolerance. Thus, autoantigen administration via mucosal routes could be useful in the preven tion of autoimmune diseases. Although in various models of autoimmune disea se it is often effective, in some cases it is ineffective and in other case s even harmful. In these cases it is likely that, concomitantly with tolera nce, a productive immune response is induced that exacerbates autoimmunity. Recent evidence suggests that induction of cytotoxic T lymphocytes capable of destroying pancreatic beta cells may be an unavoidable consequence of m ucosal administration of pancreatic beta-cell associated autoantigen. To im prove the safety and efficacy of mucosal tolerance induction in the prevent ion of type 1 diabetes, further means to control the induction of cytotoxic T lymphocytes and other potentially tissue-destructive immune effectors ma y be required.