Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

Citation
Mk. Patel et al., Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord, BR J PHARM, 130(8), 2000, pp. 1731-1734
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BRITISH JOURNAL OF PHARMACOLOGY
ISSN journal
0007-1188 → ACNP
Volume
130
Issue
8
Year of publication
2000
Pages
1731 - 1734
Database
ISI
SICI code
0007-1188(200008)130:8<1731:GIESTI>2.0.ZU;2-A
Abstract
In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin-induced diabetic neuropathy. At concentrations up to 100 mu M, bath application fai led to affect the resting membrane properties of dorsal horn neurones taken from both groups of animal. In contrast, bath application of gabapentin dr amatically reduced the magnitude of the excitatory postsynaptic current (EP SC) in neurones taken from hyperalgesic animals without altering the magnit ude of the EPSC in control animals. Using a paired pulse stimulation protoc ol, together with analysis of miniature EPSC's, it was possible to demonstr ate that gabapentin mediated these effects via a pre-synaptic site of actio n.