Serum levels of soluble interleukin-2 receptor after bone marrow transplantation: A true marker of acute graft-versus-host disease

Citation
M. Kami et al., Serum levels of soluble interleukin-2 receptor after bone marrow transplantation: A true marker of acute graft-versus-host disease, LEUK LYMPH, 38(5-6), 2000, pp. 533-540
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
38
Issue
5-6
Year of publication
2000
Pages
533 - 540
Database
ISI
SICI code
1042-8194(200008)38:5-6<533:SLOSIR>2.0.ZU;2-2
Abstract
To examine whether serum levels of soluble interleukin-2 receptor (sIL-2R) may be a good marker of acute graft-versus-host disease (aGVHD), they were determined weekly in 56 patients receiving bone marrow transplantation (BMT ). Because of wide variation in the pre-transplant sIL-2R. levels (from 135 to 1918 IU/ml), we used a sIL-2R index in this study by comparing the pr:a k levels with the pre-transplant levels. In agreement with previous reports , there was a significant correlation between the grade of aGVHD and the ma ximal sIL-2R index. The maximal sIL-2R index was 4.66 in patients with grad e I to IV aGVHD, whereas it was 2.68 in patients without GVHD. This marker may be useful for monitoring the status of aGVHD. However, it was interesti ng that sIL-2R levels were elevated from the time of transplantation until the third week even in patients without GVHD or those who received autologo us transplantation. Until the third week, no significant differences were o bserved in sIL-2R index between these patients and those who developed aGVH D during their clinical courses. After the fourth week, a higher sIL-2R ind ex was observed in patients with aGVHD than in the other patients. Some fac tors other than GVHD contribute to the elevation of serum sIL-2R levels, an d we: should recognize the limitations of the measurement of this cytokine.