In a retrospective study of 280 sera from patients presenting with cerebell
ar signs, seven of whom had proved positive for the typical paraneoplastic
serum antibodies that were requested by the clinicians, raised concentratio
ns of antibodies to voltage-gated calcium channels or to glutamic acid deca
rboxylase were detected in a further seven sera. Systematic screening for t
hese and other antibodies in future cases should help in the diagnosis and
management of the patients.