Pneumocystis carinii pneumonia as a complication of immunosuppressive therapy

Citation
T. Gluck et al., Pneumocystis carinii pneumonia as a complication of immunosuppressive therapy, INFECTION, 28(4), 2000, pp. 227-230
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
INFECTION
ISSN journal
0300-8126 → ACNP
Volume
28
Issue
4
Year of publication
2000
Pages
227 - 230
Database
ISI
SICI code
0300-8126(200007/08)28:4<227:PCPAAC>2.0.ZU;2-O
Abstract
Background: Patients receiving immunosuppressive therapy with corticosteroi ds and cytotoxic agents may develop opportunistic infections such as Pneumo cystis carinii pneumonia (PCP). This indicates a severe T-cell defect, but so far there a re no established criteria for identifying patients at risk. Patients and Methods: CD4+ and CD8+ T-lymphocyte counts were determined by flow cytometry in seven HIV-negative patients who developed PCP as a compli cation of immunosuppressive treatment. Results: CD4+ T-lymphocyte counts (T-helper phenotype) were less than 200/m u l in all seven patients (mean 90.6/mu l). The markedly reduced CD4 counts measured in these patients are similar to those observed in organ transpla nt recipients who developed PCP during immunosuppressive therapy for preven tion of graft rejection and in HIV-positive patients with PCP as an AIDS-de fining illness. Conclusion: Measuring CD4+ T-lymphocyte counts may be helpful in determinin g the risk of PCP not only in HIV-positive patients, but also in patients r eceiving immunosuppressive therapy. The risk of acqiring PCP seems to incre ase when CD4+ lymphocyte counts drop below 200/mu l, regardless of the unde rlying disease.