Manipulation of mucosa-mediated immunoregulation

Citation
Lc. Harrison et al., Manipulation of mucosa-mediated immunoregulation, IMMUNOLOGIS, 8(1-2), 2000, pp. 28-30
Citations number
16
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGIST
ISSN journal
1192-5612 → ACNP
Volume
8
Issue
1-2
Year of publication
2000
Pages
28 - 30
Database
ISI
SICI code
1192-5612(200001/04)8:1-2<28:MOMI>2.0.ZU;2-P
Abstract
Mucosal administration of antigen is known to have tolerogenic potential; h owever, it may also prime systemic cytotoxic T lymphocytes (CTL) and even e xacerbate autoimmune disease. Here, Leonard C. Harrison and colleagues use the nonobese diabetic (NOD) mouse model of diabetes to develop strategies t o minimize immunity and maximize tolerance, that have broad implications fo r other diseases.