Reactive oxygen species, cell signaling, and cell injury

Citation
K. Hensley et al., Reactive oxygen species, cell signaling, and cell injury, FREE RAD B, 28(10), 2000, pp. 1456-1462
Citations number
56
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN journal
0891-5849 → ACNP
Volume
28
Issue
10
Year of publication
2000
Pages
1456 - 1462
Database
ISI
SICI code
0891-5849(20000515)28:10<1456:ROSCSA>2.0.ZU;2-J
Abstract
Oxidative stress has traditionally been viewed as a stochastic process of c ell damage resulting from aerobic metabolism, and antioxidants have been vi ewed simply as free radical scavengers. Only recently has it been recognize d that reactive oxygen species (ROS) are widely used as second messengers t o propagate proinflammatory or growth-stimulatory signals. With this knowle dge has came the corollary realization that oxidative stress and chronic in flammation are related, perhaps inseparable phenomena. New pharmacological strategies aimed at supplementing antioxidant defense systems while antagon izing redox-sensitive signal transduction may allow improved clinical manag ement of chronic inflammatory or degenerative conditions, including Alzheim er's disease, introduction of antioxidant therapies into mainstream medicin e is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis. (C) 2000 Elsevier Sc ience Inc.