Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: a Finnish Leukaemia Group study

Citation
T. Oivanen et al., Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: a Finnish Leukaemia Group study, EUR J HAEMA, 65(2), 2000, pp. 123-127
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
EUROPEAN JOURNAL OF HAEMATOLOGY
ISSN journal
0902-4441 → ACNP
Volume
65
Issue
2
Year of publication
2000
Pages
123 - 127
Database
ISI
SICI code
0902-4441(200008)65:2<123:ALAOSN>2.0.ZU;2-N
Abstract
The occurrence of acute leukaemia and other secondary neoplasms in 432 pati ents treated with conventional chemotherapy for multiple myeloma was analys ed after a follow-up period of 11-19 yr (mean 16 yr). The number and organ- specific distribution of observed solid neoplasms was close to that expecte d in the general population. Non-Hodgkin's lymphoma developed in three pati ents (expected 0.7, p = 0.19). Acute leukaemia was diagnosed in 14 patients with an actuarial risk of 9.8% at 9 yr. No further cases were diagnosed th ereafter. The average numbers of courses (26.2 vs. 25.5) and cumulative dos es of melphalan (1440 and 1400 mg) were similar in patients with or without acute leukaemia. It seems possible that the advanced stage of multiple mye loma is more vulnerable to the leukaemogenic effect of melphalan compared w ith the earlier stages.