Intracellular osmotic action

Citation
Rp. Rand et al., Intracellular osmotic action, CELL MOL L, 57(7), 2000, pp. 1018-1032
Citations number
41
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
57
Issue
7
Year of publication
2000
Pages
1018 - 1032
Database
ISI
SICI code
1420-682X(200007)57:7<1018:IOA>2.0.ZU;2-J
Abstract
Water often acts as a critical reactant in cellular reactions. Its role can be detected by modulating water activity with osmotic agents. We describe the principles behind this 'osmotic stress' strategy, and survey the ubiqui ty of water effects on molecular structures that have aqueous, solute-exclu ding regions. These effects are seen with single-functioning molecules such as membrane channels and solution enzymes, as well as in the molecular ass embly of actin, the organization of DNA and the specificity of protein/DNA interactions.