Exploitation of the B cell repertoire for the identification of human tumor antigens

Authors
Citation
M. Pfreundschuh, Exploitation of the B cell repertoire for the identification of human tumor antigens, CANC CHEMOT, 46, 2000, pp. S3-S7
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CHEMOTHERAPY AND PHARMACOLOGY
ISSN journal
0344-5704 → ACNP
Volume
46
Year of publication
2000
Supplement
S
Pages
S3 - S7
Database
ISI
SICI code
0344-5704(200006)46:<S3:EOTBCR>2.0.ZU;2-G
Abstract
The screening of turner-derived expression libraries for antigens that are detected by high-titer immunoglobulin G antibodies from the sera of patient s with cancer using serological identification of antigens by recombinant e xpression cloning (SEREX) allows for the systematic search for antigens of human cancers. SEREX has led to the identification of a plentitude of new t umor antigens in many different tumor entities. These antigens, many of whi ch are encoded by hitherto unknown genes, can be grouped into different cla sses. Serologically defined human tumor antigens facilitate the identificat ion of antigenic peptides recognized by tumor-specific T lymphocytes, thus providing a molecular basis for polyvalent peptide-based and gene therapeut ic vaccine strategies in a wide variety of human neoplasms, Finally, many o f the antigens identified using SEREX seem to play a functional role in the pathogenesis of malignant disease.