Microcapsulated parathyroid tissue in vitro

Citation
S. Kobayashi et al., Microcapsulated parathyroid tissue in vitro, BIOMED PHAR, 54, 2000, pp. 66S-68S
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOMEDICINE & PHARMACOTHERAPY
ISSN journal
0753-3322 → ACNP
Volume
54
Year of publication
2000
Supplement
1
Pages
66S - 68S
Database
ISI
SICI code
0753-3322(200006)54:<66S:MPTIV>2.0.ZU;2-E
Abstract
Ideally, microcapsules will make it possible to transplant parathyroid tiss ue for allo- and xenotransplantation in hypoparathyroid patients. In this s tudy, parathyroid tissues capsulated by polyelectrolyte complex were evalua ted in vitro. Hormone secretion ability was significantly (P < 0.001) greater in sediment than in supernatant. There was no difference in hormone secretion ability between the parathyroid tissue thawed at room temperature and the tissue th awed in a bath at 37 degrees C. Both non-capsulated and capsulated parathyr oid tissues were incubated for three weeks. The ability of capsulated parat hyroid to secrete hormones in vitro was reduced gradually and disappeared w ithin three weeks. There are still several problems to be solved before the clinical applicati on of parathyroid allotransplantation using microcapsulation. (C) 2000 Edit ions scientifiques et medicales Elsevier SAS.