Isolated small intestinal atresias in Latin America and Spain: Epidemiological analysis

Citation
Ml. Martinez-frias et al., Isolated small intestinal atresias in Latin America and Spain: Epidemiological analysis, AM J MED G, 93(5), 2000, pp. 355-359
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
0148-7299 → ACNP
Volume
93
Issue
5
Year of publication
2000
Pages
355 - 359
Database
ISI
SICI code
0148-7299(20000828)93:5<355:ISIAIL>2.0.ZU;2-4
Abstract
Stenosis, atresia, or absence of part of the duodenum, jejunum, or ileum ar e generally considered small intestinal atresias (SIAs), SIAs occur as isol ated defects, in combination with other unrelated congenital anomalies, or as part of syndromes. We performed an epidemiological study of infants with isolated SIAs using data from two large congenital defects registries, one from Latin America (ECLAMC) and the other from Spain (ECEMC), The overall prevalence of SIAs is similar in both programs, being 1.32 per 10,000 liveb irths in Spain and 1.29 per 10,000 livebirths in Latin America. Our results suggest that infants with isolated SIAs are characterized epidemiologicall y on the basis of shorter gestational age and low birthweight, an associati on with twinning, the parents are more frequently consanguineous, and their pregnancies are more frequently complicated by vaginal bleeding. The resul ts also suggest an association between some maternal infections and ileal a tresia. The fact that these characteristics have been observed in children with these types of anomalies occurring in different geographical areas and populations supports the conclusion that these characteristics are causall y related to these defects. (C) 2000 Wiley-Liss. Inc.