K. Jinno et al., Comparison of separation behavior of benzodiazepines in packed capillary electrochromatography and open-tubular capillary electrochromatography, J CHROMAT A, 887(1-2), 2000, pp. 479-487
Packed column capillary electrochromatography (CEC), open-tubular CEC and m
icrocolumn liquid chromatography (LC) using a cholesteryl silica bonded pha
se have been studied to compare the retention behavior for benzodiazepines.
It has been found that packed column CEC gives better resolution, faster a
nalysis time than microcolumn LC for benzodiazepines maintaining similar se
lectivity except for some solutes which are charged species under the separ
ation conditions. However, open-tubular CEC gave different selectivities to
a larger extent for charged benzodiazepines from that which should be prod
uced by the chromatographic properties of the cholesteryl silica phase. Cha
rged species migration times are mainly influenced by electrophoretic mobil
ity rather than the chromatographic interactions. (C) 2000 Elsevier Science
B.V. All rights reserved.