G. Rossi et al., Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori, INFEC IMMUN, 68(8), 2000, pp. 4769-4772
Experimental infection of beagle dogs with Helicobacter pylori induces recr
uitment to the gastric mucosae of neutrophils at early stages and later of
mononuclear cells that organize into lymphoid follicles. These structures b
ecome macroscopically evident and consist of peripheral CD4(+) T lymphocyte
s and central CD21(+) B lymphocytes. Furthermore, transient expression of i
nterleukin-8 (IL-8) parallels the presence of neutrophils in the gastric mu
cosae, whereas expression of IL-6 tends to persist chronically.