Testing for endothelial dysfunction

Citation
Ot. Raitakari et Ds. Celermajer, Testing for endothelial dysfunction, ANN MED, 32(5), 2000, pp. 293-304
Citations number
121
Language
INGLESE
art.tipo
Review
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
ANNALS OF MEDICINE
ISSN journal
0785-3890 → ACNP
Volume
32
Issue
5
Year of publication
2000
Pages
293 - 304
Database
ISI
SICI code
0785-3890(200007)32:5<293:TFED>2.0.ZU;2-1
Abstract
Endothelial health is a key factor in normal cardiovascular homeostasis, an d recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control ov er arterial tone, coagulation, fibrinolysis, and vascular growth. Consequen tly, endothelial dysfunction has been implicated as an important event in t he pathogenesis of atherosclerosis, coronary vasoconstriction, hypertension , and myocardial ischaemia. Therefore, there has been considerable research interest in diagnostic assays for the assessment of endothelium. This revi ew outlines the current status of markers of endothelial dysfunction, parti cularly those related to vasomotor control, as well as circulating markers of vascular health.