Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men

Citation
N. Nakanishi et al., Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men, ANN INT MED, 133(3), 2000, pp. 183-191
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
ANNALS OF INTERNAL MEDICINE
ISSN journal
0003-4819 → ACNP
Volume
133
Issue
3
Year of publication
2000
Pages
183 - 191
Database
ISI
SICI code
0003-4819(20000801)133:3<183:CSARFI>2.0.ZU;2-Q
Abstract
Background: The contribution of cigarette smoking to development of impaire d fasting glucose and type 2 diabetes remains unclear. Objective: To investigate the association of cigarette smoking with develop ment of impaired fasting glucose and type 2 diabetes. Design: Prospective cohort study. Setting: Work site in Osaka, Japan. Participants: 1266 Japanese male office workers 35 to 59 years of age who d id not have impaired fasting glucose or type 2 diabetes and were not taking medication for hypertension at study entry. Measurements: Fasting plasma glucose levels were measured at annual health examinations from May 1994 through May 1999. Impaired fasting glucose was d efined as a fasting glucose level of at least 6.1 mmol/L (110 mg/dL) but le ss than 7.0 mmol/L (126 mg/dL). Type 2 diabetes was defined as a fasting gl ucose level of 7.0 mmol/L or more or current receipt of hypoglycemic medica tion. Results: 87 and 54 men developed impaired fasting glucose and type 2 diabet es during 5817 and 5937 person-years follow-up, respectively After controll ing for potential predictors of diabetes, the relative risk for impaired fa sting glucose compared with never-smokers was 1.62 (95% CI, 0.85 to 3.10) f or ever-smokers, 1.14 (CI, 0.58 to 2.25) for persons who smoked 1 to 20 cig arettes/d, 1.33 (CI, 0.63 to 2.80) for those who smoked 21 to 30 cigarettes /d, and 2.56 (CI, 1.32 to 4.95) for those who smoked 31 or more cigarettes/ d (P for trend for current smokers only = 0.013). The respective multivaria te-adjusted relative risks for type 2 diabetes compared with never-smokers were 1.08 (CI, 0.34 to 3.42), 1.88 (CI, 0.71 to 5.00) 3.02 (CI, 1.15 to 7.9 4), and 4.09 (CI, 1.62 to 10.29) (P for trend for current smokers only < 0. 001). The number of pack-years of exposure was also positively related to d evelopment of impaired fasting glucose and type 2 diabetes (P for trend = 0 .039 and 0.002, respectively). The relative risk for impaired fasting gluco se and type 2 diabetes in current smokers versus never-smokers was stronger among men with a body mass index less than 24.2 kg/m(2) than among men wit h a body mass index of 24.2 kg/m(2) or more, although the absolute risk was greater in more obese men. Conclusion: The number of cigarettes smoked daily and the number of pack-ye ars of exposure seem to be associated with development of impaired fasting glucose and type 2 diabetes in middle-aged Japanese men.