Effect of topical nasal azelastine on the symptoms of rhinitis, sleep, anddaytime somnolence in perennial allergic rhinitis

Citation
S. Golden et al., Effect of topical nasal azelastine on the symptoms of rhinitis, sleep, anddaytime somnolence in perennial allergic rhinitis, ANN ALLER A, 85(1), 2000, pp. 53-57
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
ISSN journal
1081-1206 → ACNP
Volume
85
Issue
1
Year of publication
2000
Pages
53 - 57
Database
ISI
SICI code
1081-1206(200007)85:1<53:EOTNAO>2.0.ZU;2-K
Abstract
Background: Recent data suggested that daytime somnolence in patients with allergic rhinitis was secondary to disrupted sleep caused by nasal congesti on. Medications, which decreased congestion, would be expected to improve s leep and daytime somnolence. Previously, we demonstrated that nasal steroid s improved all three symptoms. The effect of topical nasal antihistamines o n these symptoms has yet to be studied. Objective: The objective of this 8-week, double-blind, placebo-controlled s tudy was to determine whether topical nasal azelastine was effective at dec reasing congestion, daytime somnolence, and improving sleep. Methods: We recruited 24 subjects with perennial allergic rhinitis and rand omized them in a double-blinded, crossover fashion, to receive placebo or a zelastine two sprays BID, using Balaam's design. Questionnaires, daily diar y, and Epworth Sleepiness Scale were used as tools. The last 2 weeks of eac h 4-week treatment period were summarized, scored and compared by PROC MIXE D in SAS. Results: The analysis of the Rhinitis Severity Score showed significant imp rovement only of rhinorrhea in the azelastine group (P = .03). The symptom severity of nasal congestion and daytime somnolence was not significantly d ifferent between placebo and azelastine. Subjects considered azelastine eff ective at improving their sleep (P = .04), but daytime somnolence (P = .06) and congestion (P = .09) were not statistically improved. Conclusion: Azelastine is effective in reducing rhinorrhea and improving sl eep quality. We were unable to demonstrate that azelastine can significantl y reduce the severity of congestion or daytime somnolence.