Alterations in extracellular matrix components in transplant glomerulopathy

Citation
Hj. Jeong et al., Alterations in extracellular matrix components in transplant glomerulopathy, VIRCHOWS AR, 437(1), 2000, pp. 69-73
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
ISSN journal
0945-6317 → ACNP
Volume
437
Issue
1
Year of publication
2000
Pages
69 - 73
Database
ISI
SICI code
0945-6317(200007)437:1<69:AIEMCI>2.0.ZU;2-I
Abstract
The distribution pattern of extracellular matrix (ECM) components in transp lant glomerulopathy was studied in relation to light microscopic features, actin expression of mesangial cells, and intraglomerular inflammatory cells . Nine cases of mild (group I) and nine cases of severe (group II) transpla nt glomerulopathy were stained with antisera against fibronectin (FN), tena scin (TN), collagen types III and IV, smooth muscle actin, CD45RO, CD68, an d Ki-67 antigen. The composition of ECM was similar in the two groups. The expanded mesangium was diffusely stained by type-IV collagen, FN and TN, an d focally and weakly stained by type-III collagen and smooth muscle actin. Type-IV collagen was linearly stained along the capillary walls, imparting a double-contour feature, whereas FN and TN showed granular staining along the capillary walls. CD68 positive cells were increased in severe transplan t glomerulopathy, but this increase was not related to ECM deposition. Thes e findings suggest that increased glomerular deposition of normal and abnor mal ECM components participate in the evolution of transplant glomerulopath y.